NiCETM Prenatal Test

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01. What is NiCETM Prenatal Test?

NiCETM stands for Non-invasive Chromosome Evaluation

02. Is My Baby Normal?

This prenatal test is done by simply taking a small amount of blood (only 10mls) from the mother to check for any chromosomal defects or abnormalities, and also for checking the gender of the baby at the same time.

There is no risk to both you and your precious baby as it is non-invasive.

At GenomixLABTM, we deploy Next Generation Sequencing technologies to enable us to test the baby’s DNA which is circulating in the mother’s blood. Your baby’s DNA (cell-free fetal DNA) allows for Genome Sequencing and a comprehensive data analysis in determining the status of all the 23 sets of Chromosomes.

03. NiCETM Benefits

Using the latest advances in medical science, abnormalities in chromosomes can be detected with up to 99% accuracy without any risk to the mother or the baby when compared to traditional methods of testing (e.g. Amniocentesis, Chorionic Villus Sampling or CVS, and serum screening). Complications of Amniocentesis and Chorionic Villus Sampling (CVS) include miscarriage, haemorrhage, leaking of amniotic fluid, and infection. NiCETMPrenatal Test can be performed as early as 9 weeks of pregnancy. You can also determine the gender of your baby as early as 9 weeks of pregnancy using this advanced technology.

04. Do I need a NiCETM Prenatal Test? And how reliable is this test?

Normal babies will have a perfect 23 pairs of chromosomes; giving a total of 46. However, an extra chromosome or a missing chromosome will not make a perfect pair – in other words, having 45 or 47 chromosomes when 46 is expected1. For example, a baby that has an extra Chromosome 21 will have Down’s Syndrome. An additional Chromosome 18 leads to Edward’s Syndrome and three Chromosome 13 lead to Patau Syndrome.

Abnormal number of chromosomes is known to be the main cause of miscarriages. An abnormal number of chromosomes may result in the delivery of an abnormal child like Down’s Syndrome. With advancing age, a woman’s risk of chromosome abnormality (or aneuploidy) increases. However, recent evidence2 suggests that even amongst younger women in their 20’s, the abnormal numbers of Chromosomes of their babies are high. The need for a NiCETMPrenatal Test also increases if one has a family history of chromosome abnormality and birth defects.

NiCETMPrenatal Test will be able to detect abnormal numbers of chromosomes such as Down’s Syndrome, Edward’s Syndrome and Patau Syndrome with more than 99% accuracy. As such, the American College of Obstetrician and Gynaecologists has recommended that women, regardless of maternal age, be offered non-invasive prenatal testing (or NIPT) for aneuploidy3.

NiCETM is a comprehensive, clinically validated and non-invasive prenatal test that is used to detect the abnormalities in chromosomes.

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05. NiCETM Lab Results

NiCETMLab Results will show you if your baby has perfect pairs or abnormal number of chromosomes analysed while at the same time, be able to let you know the gender of your precious baby. If the numbers are abnormal, you may wish to obtain further advice/consultation from your Obstetrician.

06. NiCETM 3 Easy Steps:

  1. Consult Your Obstetrician.
  2. Doctors will extract a small sample of blood (10mls) from the mother and we will do the rest at our Lab.
  3. Using the latest Next Generation Sequencing (NGS) technologies, we will forward the Lab Results within 10 working days to your Obstetrician.

List of Services

  1. PGDPre-Genetic Diagnosis for a single gene
  2. PGSPre-Genetic Screening of all 23 Chromosomes
  3. PoCProducts of Conception Genetic Testing
  4. CGTCarrier Genetic Test
  5. mDNAMitochondrial DNA Test
  6. BRCA 1/2BReast CAncer 1 and 2 Genes

1 Griffiths AJ, Miller JH, Suzuki DT (2000). An Introduction to Genetic Analysis (7 ed.). pp. Ch 18

2 Yang, et al; 2012, Journal of Molecular Cytogenetics. 5:25

3 The American College of Obstetrics and Gynaecologists Committee on Genetics and The Society for Maternal-Fetal Medicine Publications Committee, Noninvasive prenatal testing for fetal aneuploidy, Committee Opinion No. 545, December 2012.